Glucosamine is well recognised and accepted across the world as a front line, joint health ingredient. It is found naturally in quite high concentration in joints and is a basic building block of certain constituents of cartilage. Glucosamine is important for maintaining elasticity, strength and resilience of cartilage, helping to reduce damage to joints. In such supplements (as with Prime Fifty), it is used in conjunction with chondroitin, also found naturally in joint tissues.

The way in which glucosamine works in largely unknown but latest theories suggest that glucosamine may help stimulate the synthesis of collagen, though this is not yet totally proven. Despite the huge body of scientific evidence across the world, surprisingly health claims for this ingredient are still being debated in Brussels within EFSA (European Food Safety Authority).